Patients with metastatic colorectal cancer (mCRC) harboring BRAF V600E mutations benefited from first-line treatment with the targeted therapies encorafenib and cetuximab plus a mFOLFOX6 chemotherapy regimen, according to results from the PhaseIII BREAKWATER trial.

Researchers have identified an unknown family of microbes uniquely adapted to the waterlogged, low-oxygen conditions of tropical peatlands in Peru’s northwestern Amazonian rainforest. The new research shows these microbes have a dual role in the carbon cycle and the potential to either moderate or intensify climate change. This process can either stabilize carbon for long-term storage or release it into the atmosphere as greenhouse gases, particularly CO2 and methane.

Scientists have developed a groundbreaking approach using specially designed peptides to improve drug formulations. This innovative method significantly enhances anti-tumor efficacy.

Researchers have used machine learning to design nano-architected materials that have the strength of carbon steel but the lightness of Styrofoam. The team describes how they made nanomaterials with properties that offer a conflicting combination of exceptional strength, light weight and customizability. The approach could benefit a wide range of industries, from automotive to aerospace.

The vestibular system is a network of organs in the inner ears that detects the motions and position of the head. The brain uses this information, along with inputs from the eyes and joints, to maintain the body’s balance. Visual information has long been proven to affect balance — for example, strobe lights and swirling images can cause instability — but a new study shows that sounds can also be a disruptive factor for those who have vestibular hypofunction, a vestibular system disorder resulting in impaired balance.

We’re nearly one month into 2025, but if you’re struggling to hold onto your New Year’s resolution, stay strong, as new research shows that forming a healthy habit can take longer than you expect. Researchers found that new habits can begin forming within about two months (median of 59-66 days) but can take up to 335 days to establish.

Successful test in breast cancer patients: the active agent digoxin, a cardiac medication, dissolves clusters of circulating breast cancer cells in the blood, thus reducing the risk of metastases formation.

Scientists have shown that specialized cells involved in how the body responds to insulin are activated in the brain after exercise, suggesting that physical activity may directly improve brain function.

Neuromorphic computing — a field that applies principles of neuroscience to computing systems to mimic the brain’s function and structure — needs to scale up if it is to effectively compete with current computing methods. Researchers, now present a detailed roadmap of what needs to happen to reach that goal.

Perovskite solar cells are a flexible and sustainable alternative to conventional silicon-based solar cells. Researchers were able to find — within only a few weeks — new organic molecules that increase the efficiency of perovskite solar cells. The team used a clever combination of artificial intelligence (AI) and automated high-throughput synthesis. Their strategy can also be applied to other areas of materials research, such as the search for new battery materials.