Every year, thousands of tons of brown algae are extracted from the seabed to obtain compounds such as alginates, a polymer composed of sugars that has high density and strength, offering potential biotechnological applications. An international team has deciphered the mechanism by which a type of enzyme, called alginate lyase (AL), is capable of degrading these marine biomaterials, allowing them to be used as carriers of drugs, additives or thickeners, among others. These results will help in the development and design of new ‘tailored alginates’ for specific applications, especially in the food and biomedical industries.

A multi-institutional team developed a chimeric antigen receptor (CAR) T cell-based strategy for specifically targeting AML cells in patients who relapsed following other treatments. The team identified a monoclonal antibody called KG2032 that reacts with a certain variant of the HLA-DRB1 molecule. KG2032 CAR T cells displayed strong anti-AML effects in a mouse model, and CAR natural killer cells showed similar results. Clinical trials are currently being planned.

Astronomers are investigating the longest and most energetic bursts of X-rays seen from a newly awakened black hole. Watching this strange behavior unfold in real time offers a unique opportunity to learn more about these powerful events and the mysterious behavior of massive black holes.

In a cave overlooking the ocean on the southern coast of South Africa, archaeologists discovered thousands of stone tools, created by ancient humans roughly 20,000 years ago. By examining tiny details in the chipped edges of the blades and stones, archaeologists are able to tell how the tools were made — which revealed that people were sharing crafting techniques over wide distances.

Heavy drinkers who have eight or more alcoholic drinks per week have an increased risk of brain lesions called hyaline arteriolosclerosis, signs of brain injury that are associated with memory and thinking problems, according to a new study.

Agronomists question statistical methods used to predict yield potential and ‘yield gaps’ for major crops. In some cases, yield potential is overestimated, while in others it can be underestimated. It’s important to have accurate information so that worldwide agriculture can meet the food demands of the growing global population.

New findings provide a greater understanding of plate subduction, or how tectonic plates slide beneath one another. This recycling of surface materials and volatile elements deep into the Earth’s interior, can impact long-term climate stability, atmospheric balance, and the habitability of our planet over billions of years.

Rhinos that flourished across much of North America 12 million years ago gathered in huge herds, according to a new study.

A hopping, insect-sized robot can jump over gaps or obstacles, traverse rough, slippery, or slanted surfaces, and perform aerial acrobatic maneuvers, while using a fraction of the energy required for flying microbots.

Wear and tear on plastic products releases small to nearly invisible plastic particles, which could impact people’s health when consumed or inhaled. To make these particles biodegradable, researchers created plastics from plant starch instead of petroleum. An initial study shows how animals consuming particles from this alternative material developed health problems such as liver damage and gut microbiome imbalances.